石云
博士，海外優(yōu)青，研究員
Email：shiyun@@m.15189803346.com
個(gè)人簡(jiǎn)介：
2007年博士畢業(yè)于佐治亞州立大學(xué)生物學(xué)系生理專業(yè)。2008-2012年在加州大學(xué)舊金山分校藥理系做博士后研究，師從Roger Nicoll院士。從2013年起相續(xù)任南京大學(xué)模式動(dòng)物研究所教授和副所長(zhǎng)，2022年任廣東省智能科學(xué)和技術(shù)研究院研究員和研究組長(zhǎng)。入選海外高層次優(yōu)秀青年人才計(jì)劃，江蘇省雙創(chuàng)人才計(jì)劃和江蘇省杰出青年。主要從事神經(jīng)突觸傳遞和可塑性機(jī)制研究。主持國(guó)家自然科學(xué)基金委基金5項(xiàng)，主持和參加科技部課題3項(xiàng)。研究成果發(fā)表在Nature, Neuron, PNAS, Brain, Cell Discovery, Cell Reports, Nature Communications, Mol Psychiatry, eLife等雜志。
認(rèn)知神經(jīng)網(wǎng)絡(luò)與可塑性研究組：
本研究組圍繞中樞興奮性神經(jīng)遞質(zhì)系統(tǒng)，研究突觸傳遞和可塑性發(fā)生的基本機(jī)理。研究?jī)?nèi)容包括谷氨酸受體和輔助亞基的基本組成、空間結(jié)構(gòu)、功能調(diào)控、合成和定位機(jī)制，從而理解興奮性突觸傳遞和可塑性發(fā)生的基本規(guī)律。課題組也以病人家系為著力點(diǎn)，建立動(dòng)物模型研究突觸紊亂和神經(jīng)認(rèn)知疾病的關(guān)系。
研究組另一個(gè)研究方向圍繞機(jī)體內(nèi)感覺系統(tǒng)的感知和神經(jīng)網(wǎng)絡(luò)展開。機(jī)體內(nèi)感覺系統(tǒng)，包括渴覺、飽饑覺、血壓感知、尿意等都是感知機(jī)械以及體內(nèi)化學(xué)信號(hào)，并由特殊的神經(jīng)網(wǎng)絡(luò)系統(tǒng)編解碼。研究組以往的研究發(fā)現(xiàn)TMEM63家族編碼了一類新型的機(jī)械和滲透壓敏感的離子通道，今后的研究將圍繞TMEM63家族通道的生理功能以及內(nèi)感覺系統(tǒng)信號(hào)的編解碼展開。
代表論著：
1. Teng XY, Hu P, Zhang CM, Zhang QX, Yang G, Zang YY, Liu ZX, Chen G, Shi YS. (2024) OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation. PNAS. 121(32):e2403652121.
2. Yang G, Jia M, Li G, Zang YY, Chen YY, Wang YY, Zhan SY, Peng SX, Wan G, Li W, Yang JJ, Shi YS. (2024) TMEM63B Channel Is the Osmosensor Required for Thirst Drive of Interoceptive Neurons. Cell Discovery, 10(1):1
3. Shi T, Shen S, Shi Y, Wang Q, Zhang G, Lin J, Chen J, Bai F, Zhang L, Wang Y, Gong W, Shao X, Chen G, Yan W, Chen X, Ma Y, Zheng L, Qin J, Lu K, Liu N, Xu Y, Shi YS, Jiang Q, Guo B (2024) Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression. Nature Metabolism, Online ahead of print.
4. Rinaldi B, Bayat A, Zachariassen LG, Sun JH, Ge YH, Zhao D, Bonde K, Madsen LH, Awad IAA, Bagiran D, Sbeih A, Shah SM, El-Sayed S, Lyngby SM, Pedersen MG, Stenum-Berg C, Walker LC, Krey I, Delahaye-Duriez A, Emrick LT, Sully K, Murali CN, Burrage LC, Plaud Gonzalez JA, Parnes M, Friedman J, Isidor B, Lefranc J, Redon S, Heron D, Mignot C, Keren B, Fradin M, Dubourg C, Mercier S, Besnard T, Cogne B, Deb W, Rivier C, Milani D, Bedeschi MF, Di Napoli C, Grilli F, Marchisio P, Koudijs S, Veenma D, Argilli E, Lynch SA, Au PYB, Ayala Valenzuela FE, Brown C, Masser-Frye D, Jones M, Patron Romero L, Li WL, Thorpe E, Hecher L, Johannsen J, Denecke J, McNiven V, Szuto A, Wakeling E, Cruz V, Sency V, Wang H, Piard J, Kortüm F, Herget T, Bierhals T, Condell A, Zeev BB, Kaur S, Christodoulou J, Piton A, Zweier C, Kraus C, Micalizzi A, Trivisano M, Specchio N, Lesca G, M?ller RS, Tümer Z, Musgaard M, Gerard B, Lemke JR, Shi YS, Kristensen AS.(2023) Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes. Brain, Online ahead of print.
5. Qin Y, Yu D, Wu D, Dong J, Li WT, Ye C, Cheung KC, Zhang Y, Xu Y, Wang Y, Shi YS, Dang S. (2023) Cryo-EM structure of TMEM63C suggests it functions as a monomer. Nature Communications, 14(1):7265.
6. Peng SX, Pei J, Rinaldi B, Chen Jiang, Ge YH, Jia M, Wang J, Delahaye-Duriez A, Sun J, Zang YY, Shi YY, Zhang N, Gao X, Milani D, Xu X, Sheng N, Gerard B, Chen Zhang C, Bayat A, Liu N, Yang JJ, Shi YS. (2022) Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. Mol Psychiatry, 27(10):4092-4102.
7. Li QQ, Chen J, Hu P, Jia M, Sun JH, Feng HY, Qiao FC, Zang YY, Shi YY, Chen G, Sheng N, Xu Y, Yang JJ, Xu Z, Shi YS. (2022) Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory. Mol Psychiatry, 27(8):3468-3478.
8. He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y. (2021) Kainate receptor modulation by Neto2. Nature, 599(7884):325-329.
9. Jiang CH, Wei M, Zhang C, Shi YS. (2021) The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65. PNAS,118(9):e2019194118.
10. Du H, Ye C, Wu D, Zang YY, Zhang L, Chen C, He XY, Yang JJ, Hu P, Xu Z, Wan G, Shi SY. (2020) The cation channel TMEM63B is an osmosensor required for hearing. Cell Reports, 31:107596.
11. Duan GF, Xu S, Ye Y, Tao W, Nicoll RA,Shi YS, and Sheng N.(2018) Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nature Communications, 9(1):4879.
12. Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA. (2018) LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. PNAS, 115(15):3948-3953.
13. Sheng N, Shi YS, Nicoll RA. (2017) The amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking. PNAS, 114(5):1159-1164.
14. Niu Y, Dai Z, Liu W, Zhang C, Yang Y, Guo Z, Li X, Xu C, Huang X, Wang Y, Shi YS, Liu JJ. (2017) Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. eLife, 6. pii: e20991.
15. He XY, Li YJ, Kalyanaraman C, Qiu LL, Chen C, Xiao Q, Liu WX, Zhang W, Yang JJ, Chen G, Jacobson MP, Shi YS. (2016) GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. PNAS, 113(38):E5645-54.
16. Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013) LTP requires an extrasynaptic pool of glutamate receptors independent of subunit type. Nature, 493(7433)，495-500
17. Herring B, Shi Y, Suh YH, Zheng CY, Schmid SM, Roche KW, Nicoll RA. (2013) Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron, 77(6),1083-96
18. Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA. (2011) Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: analysis of single-cell GluN2 subunit deletion in vivo. Neuron, 71(6), 1085-1101
19. Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll RA. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. PNAS, 107(37), 16315-16319
20. Shi Y, Lu W, Milstein AD, Nicoll RA. (2009) The stoichiometry of AMPA receptors and TARPs varies by neuronal cell types. Neuron, 62(5), 633-40
21. Lu W, Shi Y, Jackson A, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron, 62(2), 254-68
