Dan Larhammar
研究員，研究組組長，博士生導師，瑞典皇家科學院院士，歐洲科學院院士
Email: danlarhammar@@m.15189803346.com
個人簡介：
Dan Larhammar，研究員，認知與衰老研究組組長。瑞典皇家科學院院士、歐洲科學院院士、國際科學理事會會士、烏普薩拉大學分子細胞生物學教授、瑞典皇家科學院院長（2018-2022）。他于1984年獲得瑞典烏普薩拉大學醫(yī)學科學博士學位，早期研究集中在對食欲調(diào)節(jié)有重要作用的神經(jīng)肽Y（NPY）的功能。作為訪問學者在加利福尼亞斯克里普斯研究所工作一年后，他專注于NPY受體的克隆和分子藥理學研究，發(fā)現(xiàn)了多個NPY受體，闡明了其在脊椎動物中的進化過程及藥理學特性。隨后他的研究擴展到了脊椎動物眼睛的分子進化，特別是視網(wǎng)膜中桿狀細胞和錐狀細胞的起源，以及神經(jīng)遞質(zhì)和激素及其受體的進化，還研究了與帕金森病相關(guān)的多巴胺受體。近年來，他致力于研究學習和長期記憶的分子機制，重點關(guān)注谷氨酸受體（AMPA和NMDA家族）及其相關(guān)的調(diào)節(jié)蛋白。
認知與衰老研究組
本研究組圍繞學習和記憶的機制主要開展兩方面的研究：一方面聚焦于研究谷氨酸受體在學習和記憶的過程中的功能以及其與各種調(diào)節(jié)蛋白質(zhì)相互作用的復雜機制；另一方面開展對于糖胺聚糖如乙酰硫酸肝素和硫酸軟骨素在學習和腦衰老過程中的研究。這些研究工作通過利用轉(zhuǎn)基因斑馬魚、小鼠以及細胞模型來開展。
相關(guān)的研究方法包括利用單細胞RNA測序分析識別與長期記憶相關(guān)的細胞群體和基因，利用空間轉(zhuǎn)錄組學分析確定學習和記憶相關(guān)腦區(qū)表達的關(guān)鍵分子，利用野生型和轉(zhuǎn)基因型斑馬魚進行學習和記憶的行為研究，還使用小鼠和斑馬魚模型研究阿爾茨海默病的發(fā)生機制。
近期代表性論著
（全部論著見網(wǎng)站：https://www.uu.se/en/contact-and-organisation/staff?query=N96-4750）
196. Criveanu, D., Bergqvist, C. A., Larhammar, D., and Walczewska-Szewc, K. Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics. Int. J. Biol. Macromol. 9;247:125771 (2023). PMID: 37433419.
195. Lagman, D., Haines, H. J., Abalo, X. M., and Larhammar, D. Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before re-expansion by whole genome duplications in vertebrates. PLOS ONE, e0279548 (2022). PMID: 36584110.
194. Morini, M., Bergqvist, C. A., Asturiano, J. F., Larhammar, D., and Dufour, S. Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses. Front. Endocrinol. 13:1013868 (2022). PMID: 36387917.
193. Li, Y., Pan, Y., Wang, Y., Jiang, Z., Akakuru, O. U., Li, M., Zhang, X., Yuan, B., Xing, J., Luo, L., Larhammar, D., Wu, A., Li, J. A D-peptide ligand of neuropeptide Y receptor Y1 serves as nanocarrier traversing of the blood brain barrier and targets glioma. Nano Today 44, 101465 (2022).
192. Ocampo Daza, D., Bergqvist, C. A., and Larhammar, D. The evolution of oxytocin and vasotocin receptor genes in jawed vertebrates: a clear case for gene duplications through ancestral whole-genome duplications. Frontiers Endocrinol. 264, 94-112 (2022). PMID: 35185783.
191. Garcia Concejo, A. and Larhammar, D. Protein kinase C family evolution in jawed vertebrates. Dev. Biol. 479, 77-90 (2021). PMID: 34329618.
188. Abalo, X. M., Lagman, D., Heras, G., Del Pozo, A., Eggert, J., and Larhammar, D. Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods: Implications for photopic and scotopic vision. Vision Res. 166, 43-51 (2020). PMID: 31855667.
186. Shebanits, K., Vasile, S., Xu, B., Gutiérrez-de-Terán, H., and Larhammar, D. Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R. Neuropeptides 76:101933 (2019). PMID: 31230758.
184. Pedersen, J. E., Bergqvist, C. A., and Larhammar, D. Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evol. Biol. 19:38 (2019). PMID: 30700248.
183. Pedersen, J. E., Bergqvist, C. A., and Larhammar, D. Evolution of the muscarinic acetylcholine receptors in vertebrates. eNeuro 5, 1-12 (2018). PMID: 30564629.
181. Shebanits, K., Andersson-Assarsson, J. C., Larsson, I., Carlsson, L. M. S., Feuk, L., and Larhammar, D. Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference. PLOS ONE 13(4):e0194668 (2018). PMID: 29621259.
180. Yang, Z., Han, S., Keller, M., Burkert, K., Bender, B. J., Bosse, M., Kaiser, A., K?gler, L. M., Wifling, D., Bernhardt, G., Plank, N., Littmann, T., Schmidt, P., Yi, C., Li, B., Ye, S., Zhang, R., Xu, B., Larhammar, D., Stevens, R. C., Huster, D., Meiler, J., Zhao, Q., Beck-Sickinger, A. G., Buschauer, A., and Wu, B. Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. Nature 556, 520-524 (2018). PMID: 29670288.
178. Ocampo Daza D. and Larhammar D. Evolution of the growth hormone (GH), prolactin (PRL) and somatolactin (SL) family. Gen. Comp. Endocrinol. 264, 94-112 (2018). PMID: 29339183.
177. Ocampo Daza, D. and Larhammar, D. Evolution of the receptors for growth hormone, prolactin, erythropoietin and thrombopoietin in relation to the vertebrate tetraploidizations. Gen. Comp. Endocrinol. 257, 143-160 (2018). PMID: 28652136.
176. Lagman, D., Franzén, I. E., Eggert, J., Larhammar, D., and Abalo, X. M. Evolution and expression of phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evol. Biol., 16:124 (2016). PMID: 27296292.
174. Xu, B., Lagman, D., Sundstr?m, G., and Larhammar, D. Neuropeptide Y family receptors Y1 and Y2 from sea lamprey, Petromyzon marinus. Gen. Comp. Endocrinol. 222, 106-115 (2015). PMID: 26255155.
Review article #15. Elphick, M. R., Mirabeau, O., and Larhammar, D. Evolution of neuropeptide signalling systems. J. Exp. Biol. 9, 221 (2018). PMID: 29440283. Correction in PMID: 30305362.
