王斌
博士，研究員，研究組組長，致力于腦認(rèn)知神經(jīng)網(wǎng)絡(luò)發(fā)育和疾病的機(jī)理研究
Email：wangbin@@m.15189803346.com
個(gè)人簡介：
王斌，研究員，腦認(rèn)知神經(jīng)網(wǎng)絡(luò)發(fā)育和疾病研究組組長。分別于2003年7月和2006年7月在西北大學(xué)生命科學(xué)學(xué)院獲得理學(xué)學(xué)士和碩士學(xué)位。2011年11月畢業(yè)于中國科學(xué)院上海生命科學(xué)研究院，獲理學(xué)博士學(xué)位。2011年12月至2018年12月在中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所任博士后、副研究員。2019年1月起任上海腦科學(xué)與類腦研究中心副研究員。2021年9月起擔(dān)任廣東省智能科學(xué)與技術(shù)研究院研究員、研究組長。曾獲得中國博士后面上以及特別項(xiàng)目、中科院上海生科院博士后以及上海博士后、中國科學(xué)院青年創(chuàng)新促進(jìn)會會員以及國家自然科學(xué)基金面上項(xiàng)目等資助。研究成果發(fā)表于Cell Research, Cell Reports, EMBO Reports, Brain 和eLife等雜志。
研究方向：
腦認(rèn)知神經(jīng)網(wǎng)絡(luò)發(fā)育和疾病
Laboratory of Cognitive Neural Network Development and Disorder
腦認(rèn)知神經(jīng)網(wǎng)絡(luò)發(fā)育和疾病研究組：
認(rèn)知是人類大腦皮層復(fù)雜高級功能的反映。認(rèn)知障礙相關(guān)疾病包括由于遺傳缺陷導(dǎo)致的智力發(fā)育異常以及由衰老和環(huán)境因素等綜合因素導(dǎo)致的認(rèn)知功能和神經(jīng)網(wǎng)絡(luò)連接異常的疾病，主要代表為智力發(fā)育障礙（Intellectual disability, ID）和阿爾茨海默病（Alzheimer diseases, AD）。智力發(fā)育障礙是一種適應(yīng)和智力能力存在缺陷的廣義性神經(jīng)發(fā)育障礙，而阿爾茨海默病是一種以認(rèn)知和記憶損傷的神經(jīng)退行性疾病。目前仍缺乏大規(guī)模的中國ID和AD基因組和RNA轉(zhuǎn)錄本測序的數(shù)據(jù)庫，且對于他們的致病機(jī)理仍遠(yuǎn)未研究清楚。
本課題組致力于腦認(rèn)知神經(jīng)網(wǎng)絡(luò)發(fā)育和疾病的機(jī)理研究。通過對中國人群先天性智力障礙兒童進(jìn)行全基因組和非編碼RNA測序分析，建立遺傳疾病資源庫和數(shù)據(jù)庫。結(jié)合大數(shù)據(jù)分析、人工智能機(jī)器學(xué)習(xí)等方法對其中潛在的致病基因及其變異進(jìn)行篩選。進(jìn)一步通過構(gòu)建疾病相關(guān)的人類iPSC、類器官及人源化轉(zhuǎn)基因小鼠等研究手段，探索這些基因變異對神經(jīng)系統(tǒng)細(xì)胞功能、小鼠學(xué)習(xí)、認(rèn)知和認(rèn)知相關(guān)神經(jīng)網(wǎng)絡(luò)連接的影響，揭示其致病性和作用機(jī)理，為腦認(rèn)知障礙疾病的早期篩查和治療方案提供重要的理論依據(jù)。
本課題組招收2025年度與澳門大學(xué)聯(lián)合培養(yǎng)的博士研究生（申請考核制）。歡迎具有生物學(xué)/醫(yī)學(xué)背景的本科或碩士畢業(yè)生申請，具備神經(jīng)科學(xué)研究背景者優(yōu)先。有意者請將個(gè)人簡歷發(fā)送至wangbin@m.15189803346.com。
期待您的加入，共同推動(dòng)腦科學(xué)領(lǐng)域的前沿研究！
代表論著：
(1) Li YY, Quan XP, Hu JC, Han Y, Chen JF, Zhou MF, Zhang F, Yang YY, Liao MC, Wang B, Zhao YH (2025). BMSCs-derived small extracellular vesicles antagonize cerebral endothelial Caveolin-1 driven autophagic degradation of tight-junction proteins to protect blood-brain barrier post-stroke. International Journal of Biological Sciences, 21(2): 842-859. doi: 10.7150/ijbs.101937
(2) Zhao X#, Yan P#, Chen NX, Han TT, Wang B*, Hu YM* (2024). Development and validation of a predictive model for identifying sarcopenia in Chinese adults using nutrition indicators (AHLC). Frontiers in Nutrition, Dec 12:11:1505655. doi: 10.3389/fnut.2024.1505655. (# Co-first authors and * Corresponding authors)
(3) Wang B#,*,Jiang BW#, Li G-W#, Dong F, Luo Z, Cai B, Wei MY, Huang JS, Wang KK, Feng X, Tong F, Han QJ, Li CL, Zhang X, Yang L* and Bao L* (2022). somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Reports, e54313. DOI: 10.15252/embr.202154313. (# Co-first authors and * Corresponding authors).
(4) Huang JS, Jiang BW, Li G-W, Zheng DD, Li MY, Xie X, Pan YX, Wei MY, Liu XY, Jiang XY, Zhang X, Yang L, Bao L*, Wang B* (2022). m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Reports, 41(8):11693. (* Corresponding authors).
(5) Yin QQ, Sun LB, Cai XJ, Lou FZ, Sun Y, Wang B, Jiang BW, Bao L, Li X, Song NN, Tang SB, Bai J, Wang ZK, Wu Y, Zhou H, Wang H, Yu BW, Li QF, Wang HL (2022). Lidocaine ameliorates psoriasis by obstructing pathogenic CGRP signaling-mediated sensory neuron-derived cell communication. Journal of Investigative Dermatology, DOI: 10.1016/j.jid.2022.01.002.
(6) Wei MY, Huang JS, Li G-W, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L, Bao L* and Wang B* (2021). Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation. Cell Reports, 35 109053, 1-15. (* Corresponding authors).
(7) Pan XY, Zhao JR, Zhou ZY, Chen JJ, Yang ZX, Wu YX, Bai MZ, Jiao Y, Yang Y, Hu XY, Cheng TL, Lu QY, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu JM, Xiao HS, Qiu ZL, Li JS, Wang ZF, Hui JY, Bao L, Zhang X. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability. eLife, 10: e63021. DOI: https://doi.org/10.7554/eLife.63021.
(8) Jiang BW, Bao L and Wang B* (2019). Isolation of Cell-Type-Specific Neurons in Mouse Dorsal Root Ganglion by FACS. Bio-101 e1010323., 2019, Doi: 10.21769/BioProtoc.1010323. (* Corresponding author)
(9) Wang B and Bao L (2017). Axonal microRNAs: localization, function and regulatory mechanism during axon development. Journal of Molecular Cell Biology, 9: 82-90. (Cover story)
(10) Wang B #, Pan L#, Wei MY, Wang Q, Liu WW, Wang NX, Jiang XY, Zhang X and Bao L (2015). FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Reports, 13: 2794-2807. (# Co-first authors)
(11) Chen XQ #, Wang B #, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L (2012). Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Research, 22: 677-696. (# Co-first authors)
(12) Liu XJ, Zhang FX, Liu H, Li KC, Lu YJ, Wu QF, Li JY, Wang B, Wang Q, Lin LB, Zhong YQ, Xiao HS, Bao L, Zhang X (2012). Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain, 135: 391-403.
(13) Ma GQ, Wang B, Wang HB, Wang Q and Bao L (2008). Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 2008; 9: 2165–2179.
